The Patient-Centered Outcomes Research Institute today approved awards totaling more than $64 million to fund five large patient-centered comparative effectiveness studies to answer key clinical questions about care for cancer, back pain and stroke. The awards are the first through PCORI’s Pragmatic Clinical Studies Initiative, an effort to produce results that are broadly applicable to a variety of patients and care situations and can be more quickly taken up in routine clinical practice. “We believe these studies can answer major gaps in our knowledge and have the potential to change practice and improve patients’ outcomes,” said PCORI Executive Director Joe Selby, M.D.