The National Academy of Medicine’s Vital Directions for Health and Health Care Initiative today proposed four policy priorities for the administration and health care leaders to achieve better health at lower cost: pay for value, empower people, activate communities and connect care. To support these priorities, the report also calls for policy reforms to measure what matters most, modernize skills, accelerate real-world evidence, and advance science. The report summarizes 19 papers and a national symposium that examined the issue as part of the initiative over the past 18 months.