The Drug Enforcement Administration today issued its proposed 2019 aggregate production quotas for certain controlled substances, which the agency said would reduce manufacturing quotas for six frequently misused opioids by an average 10 percent. The proposed rule will be published in the Aug. 20 Federal Register with comments accepted for 30 days. AHA and others have urged DEA to include drug shortages as a factor when setting and adjusting aggregate and individual manufacturers’ production quotas for controlled substances.